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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Big 4 Journals

Big 4 Journals current awareness bulletin

The BMJ, JAMA, The Lancet, New England Journal of Medicine

Frequency: weekly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

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This bulletin is based on the equivalent bulletin produced by Bodleian Health Care Libraries:

1st December 2025

The BMJ: 1st December 2025

Arthroscopic subacromial decompression versus placebo surgery for subacromial pain syndrome: 10 year follow-up of the FIMPACT randomised, placebo surgery controlled trial

Clinical competencies for using generative AI in patient care

Impact of population based breast density notification: multisite parallel arm randomised controlled trial in BreastScreen

Responding to public health challenges of medical advice from social media influencers

JAMA: 2nd December 2025

Discordance in creatinine- and cystatin C–based eGFR and clinical outcomes: a meta-analysis

Individualized perioperative blood pressure management in patients undergoing major abdominal surgery: the IMPROVE-multi randomized clinical trial

Proactive vs reactive treatment of hypotension during surgery: the PRETREAT randomized clinical trial

Syphilis: a review

The Lancet: 6th December 2025

The effects of government-led cash transfer programmes on behavioural and health determinants of mortality: a difference-in-differences study

Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial

Policies to halt and reverse the rise in ultra-processed food production, marketing, and consumption

Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study

Towards unified global action on ultra-processed foods: understanding commercial determinants, countering corporate power, and mobilising a public health response

Ultra-processed foods and human health: the main thesis and the evidence

New England Journal of Medicine: 4th December 2025

Idiopathic normal-pressure hydrocephalus

A pragmatic trial of glucocorticoids for community-acquired pneumonia

A randomized trial of shunting for idiopathic normal-pressure hydrocephalus

Simplify or stratify? The debate over medical school grading systems

Trial of pegcetacoplan in C3 glomerulopathy and immune-complex MPGN

Updated evidence for Covid-19, RSV, and influenza vaccines for 2025–2026

24th November 2025

The BMJ: 27th November 2025

Changes to UK soft drinks tax are a missed opportunity for public health

Effects of extreme heat on physiology, morbidity, and mortality under climate change: mechanisms and clinical implications

Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (PREVENT-TAHA8)

Risk of infection and wound dehiscence after use of prophylactic antibiotics in episiotomy or second degree tear (REPAIR study): single centre, double blind, placebo controlled randomised trial

JAMA: 25th November 2025

A direct-to-patient digital health program for lung cancer screening: a randomized clinical trial

Eltrombopag for newly diagnosed pediatric immune thrombocytopenia requiring treatment: the PINES randomized clinical trial

Long-term continuous monitoring of new-onset atrial fibrillation after coronary artery bypass grafting

Lung cancer in nonsmoking individuals: a review

The Lancet: 29th November 2025

Contemporary, non-invasive imaging diagnosis of chronic coronary artery disease

Efficacy and safety of REGN9933A2 and REGN7508Cat for preventing postoperative venous thromboembolism (ROXI-VTE-I and ROXI-VTE-II): two randomised, open-label, phase 2 trials

Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial

Health care in the USA: money has become the mission

Percutaneous transcatheter valve replacement in individuals with mitral regurgitation unsuitable for surgery or transcatheter edge-to-edge repair: a prospective, multicountry, single-arm trial

New England Journal of Medicine: 27th November 2025

Daily mosnodenvir as dengue prophylaxis in a controlled human infection model

Early withdrawal of aspirin after PCI in acute coronary syndromes

Early discontinuation of aspirin after PCI in low-risk acute myocardial infarction

Engasertib versus placebo for bleeding in hereditary hemorrhagic telangiectasia

Medical education: strategies to reinvigorate the bedside clinical encounter

Phase 1 trial of CRISPR-Cas9 gene editing targeting ANGPTL3

17th November 2025

The BMJ: 17th November 2025

Advances in the management of gastric cancer

Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study

Generative AI and the changing dynamics of clinical consultations

Gestational weight gain and risk of adverse maternal and neonatal outcomes in observational data from 1.6 million women: systematic review and meta-analysis

Paralysed by migraine

Targeted therapy in advanced BRAF-mutated colorectal cancer: systematic review and network meta-analysis

JAMA: 18th November 2025

Bioresorbable vs metallic occluders for transcatheter atrial septal defect closure: a randomized clinical trial

Hypothyroidism: a review

Intra-arterial alteplase after successful endovascular reperfusion in acute stroke (PEARL RCT)

Respiratory gas shifts to delay asphyxiation in critical avalanche burial: a randomized clinical trial

The Lancet: 22nd November 2025

Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial

Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis

Efficacy and safety of nipocalimab in patients with moderate-to-severe Sjögren's disease (DAHLIAS): a randomised, phase 2, placebo-controlled, double-blind trial

Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023

Non-coeliac gluten sensitivity

Peripartum cardiomyopathy

New England Journal of Medicine: 20th November 2025

Belzutifan for advanced pheochromocytoma or paraganglioma

Efficacy, immunogenicity, and safety of modified mRNA influenza vaccine

Increasing the potassium level in patients at high risk for ventricular arrhythmias

Long QT syndrome

A new stage for seasoned actors — food anaphylaxis and the cysteinyl leukotrienes

Reduction of antihypertensive treatment in nursing home residents

Watchful waiting or oral antihypertensives for asymptomatic inpatient hypertension

Why have we chosen not to fix primary care? The vicious cycle of medical hierarchy

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