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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Guidelines and Cochrane Reviews

Guidelines and Cochrane Reviews

Frequency: Monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

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December 2025

All content new, unless marked as ‘updated’

Cochrane reviews

Antibiotics for the common cold and acute purulent rhinitis

Breast surgery for metastatic breast cancer (updated)

Colchicine for the secondary prevention of cardiovascular events

Cyproterone acetate for hirsutism (updated)

Decongestants and antihistamines for acute otitis media in children

Dipeptidyl peptidase 4 (DPP‐4) inhibitors for people with chronic kidney disease and diabetes

Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV‐related disease and harms from vaccination

Electronic cigarettes for smoking cessation (updated)

Governance arrangements for rehabilitation services in health systems: an overview of systematic reviews

High‐frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term

Human papillomavirus (HPV) vaccination for the prevention of cervical cancer and other HPV‐related diseases: a network meta‐analysis

Human stem cells for decompensated cirrhosis in adults

Indications and timings for caffeine initiation in preterm infants

Interventions for quitting vaping (updated)

Interventions for treating urinary incontinence in older women: a network meta‐analysis

Long‐term hormone therapy for perimenopausal and postmenopausal women (updated)

Non‐invasive ventilation for cystic fibrosis (updated)

Nucleoplasty for cervical radicular pain due to disc herniation

Rapid, point‐of‐care antigen tests for diagnosis of SARS‐CoV‐2 infection (updated)

Septum resection for women of reproductive age with a septate uterus (updated)

Thiazolidinediones for people with chronic kidney disease and diabetes

Topical immunosuppressants for blepharitis in adults

NICE guidelines

Abiraterone (originator and generics) for treating newly diagnosed high-risk hormone‑sensitive metastatic prostate cancer (TA1110)

Cabotegravir for preventing HIV-1 in adults and young people (TA1106)

Cemiplimab with platinum-based chemotherapy for untreated advanced non-small-cell lung cancer (TA1108)

Darolutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancer (TA1109)

Delgocitinib for treating moderate to severe chronic hand eczema (TA1107)

Fetal monitoring in labour (NG229 - updated)

Intrapartum care (NG235 - updated)

Low-energy contact X-ray brachytherapy for rectal cancer (IPG809)

Suspected sepsis in over 16s (QS213)

Suspected sepsis in people aged 16 or over: recognition, assessment and early management (NG253)

Suspected sepsis in pregnant or recently pregnant people: recognition, diagnosis and early management (NG254)

Suspected sepsis in under 16s: recognition, diagnosis and early management (TA1112)

WHO guidelines

Guideline for the prevention, diagnosis and treatment of infertility

Medical eligibility criteria for contraceptive use, 6th ed.

Selected practice recommendations for contraceptive use, 4th ed.

Sources

Cochrane Library (Nov); NICE website (Nov); WHO website (Nov)

November 2025

All content new, unless marked as ‘updated’

Cochrane reviews

Acupuncture for polycystic ovary syndrome (updated)

Cognitive behavioural therapy for insomnia in people with cancer

Cryotherapy following total knee replacement

Duct‐to‐mucosa versus other types of pancreaticojejunostomy for the prevention of postoperative pancreatic fistula following pancreaticoduodenectomy (updated)

Electronic cigarettes for smoking cessation (updated)

Hormone therapy in postmenopausal women and risk of endometrial hyperplasia or endometrial cancer (updated)

Immediate or early skin‐to‐skin contact for mothers and their healthy newborn infants (updated)

Immunoglobulin for myasthenia gravis

Intraperitoneal chemotherapy for gastric cancer

Liraglutide for adults living with obesity

Molnupiravir for treating COVID‐19

Oral nicotine pouches for cessation or reduction of use of other tobacco or nicotine products

Pharmacological and non‐pharmacological treatments for impulsive‐compulsive behaviors in Parkinson's disease

Pharmacotherapy for hypertension in adults 60 years or older (updated)

Prevention of infection in peripheral arterial reconstruction of the lower limb

Progestagens for pain symptoms associated with endometriosis (updated)

Prognostic factors predicting an unprovoked seizure recurrence in children and adults following a first unprovoked seizure

Propofol for sedation during colonoscopy (updated)

Pyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria (updated)

Riboflavin supplements for blood pressure lowering in adults

Semaglutide for adults living with obesity

Service delivery, behavioural, and self‐management interventions for children with epilepsy

Simple hysterectomy with pelvic lymphadenectomy versus radical hysterectomy with pelvic lymphadenectomy for women with stage IA2‐IB1 cervical cancer

Tirzepatide for adults living with obesity

Transfusion thresholds and other strategies for guiding red blood cell transfusion (updated)

Work‐break interventions for preventing musculoskeletal symptoms and disorders in healthy workers (updated)

Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children (updated)

NICE guidelines

Artificial intelligence (AI) technologies to aid opportunistic detection of vertebral fragility fractures: early value assessment (HTE34)

Durvalumab for treating limited-stage small-cell lung cancer after platinum-based chemoradiotherapy (TA1099)

Garadacimab for preventing recurrent attacks of hereditary angioedema in people 12 years and over (TA1101)

Head injury (QS74 – updated)

Lorlatinib for ALK-positive advanced non-small-cell lung cancer that has not been treated with an ALK inhibitor (TA1103)

Rehabilitation for chronic neurological disorders including acquired brain injury (NG252)

Sparsentan for treating primary IgA nephropathy (TA1074 - updated)

Targeted-release budesonide for treating primary IgA nephropathy (TA937 - updated)

VA ECMO for extracorporeal cardiopulmonary resuscitation (ECPR) in adults with refractory cardiac arrest (IPG808)

VA ECMO for severe acute heart failure in adults (IPG807)

Sources

Cochrane Library (Oct); NICE website (Oct)

October 2025

All content new unless specified as updated

Cochrane reviews

Antibiotic prophylaxis for corneal abrasion (updated)

Calcium supplementation commenced before pregnancy for preventing hypertensive disorders and related problems (updated)

Combined cardiorespiratory and resistance training for people with stroke

Efficacy and safety of respiratory syncytial virus vaccines

Human papillomavirus (HPV) vaccination in women with conisation

Misoprostol for intrauterine device placement

Models of care for children and adolescents with type 1 diabetes in low‐ and middle‐income countries: a scoping review

Omega‐3 fatty acid supplementation for distal symmetrical peripheral neuropathy in adults with diabetes mellitus

Opioid agonist therapy for opioid use disorder in primary versus specialty care

Pharmacotherapies for cannabis use disorder (updated)

Pharmacotherapy for mild hypertension (updated)

Probiotics for the prevention of Clostridioides difficile‐associated diarrhea in adults and children (updated)

Prognostic models for radiation‐induced complications after radiotherapy in head and neck cancer patients

Remote ischaemic conditioning for preventing and treating ischaemic stroke (updated)

Resistance training for people with stroke

Service delivery, behavioural, and self‐management interventions for adults with epilepsy

Single‐incision versus conventional multi‐incision laparoscopic appendicectomy for suspected uncomplicated appendicitis

Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting: a network meta‐analysis (updated)

Synchronised approach for intrauterine insemination in subfertile couples (updated)

Virtual reality simulation training for health professions trainees in gastrointestinal endoscopy (updated)

NICE guidelines

Atopic eczema in under 12s: diagnosis and management (CG57 – updated)

Benralizumab for treating relapsing or refractory eosinophilic granulomatosis with polyangiitis (TA1096)

Bipolar disorder: assessment and management (CG185 – updated)

Chronic heart failure in adults (QS9 – updated)

Chronic heart failure in adults: diagnosis and management (NG106 – updated)

Digital technologies to deliver pulmonary rehabilitation programmes for adults with COPD: early value assessment (HTE18 – updated)

Digital technologies to support self-management of COPD: early value assessment (HTE19 – updated)

DMD Care UK's guideline on cardiac care of children with dystrophinopathy and females carrying DMD-gene variations: NICE review (NG251)

Enfortumab vedotin with pembrolizumab for untreated unresectable or metastatic urothelial cancer when platinum-based chemotherapy is suitable (TA1097)

HIV testing: increasing uptake among people who may have undiagnosed HIV (NG60 – updated)

Isatuximab in combination for untreated multiple myeloma when a stem cell transplant is unsuitable (TA1098)

Pneumonia: diagnosis and management (NG250)

Pneumonia: diagnosis and management (QS110 – updated)

Suspected acute respiratory infection in over 16s: assessment at first presentation and initial management (NG237)

Tirzepatide for managing overweight and obesity (TA1026 – updated)

Tirzepatide for treating type 2 diabetes (TA924 - updated)

SIGN guidelines

Trusted Advice on paracetamol in pregnancy

WHO guidelines

WHO guideline on HIV service delivery (updated)

Sources: Cochrane Library (Sep); NICE website (Sep); SIGN website (Sep); WHO website (Sep)

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