HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Guidelines and Cochrane Reviews

Guidelines and Cochrane Reviews

Frequency: Monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

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April 2025

All content new unless specified as updated

Cochrane reviews

Antibiotic treatment for non‐tuberculous mycobacteria lung infection in people with cystic fibrosis

Antidepressants for low back pain and spine‐related leg pain (updated)

Audit and feedback: effects on professional practice (updated)

Cervical preparation for dilation and evacuation at 12 to 24 weeks gestation (updated)

Combined pharmacological and psychosocial interventions for alcohol use disorder

Effect of adrenergic agonist oral decongestants on blood pressure

Effect of amphetamines on blood pressure

Generalized Anxiety Disorder 7‐item (GAD‐7) and 2‐item (GAD‐2) scales for detecting anxiety disorders in adults

Models of care for managing non‐specific low back pain

Molecular assays for the diagnosis of sepsis in neonates: a diagnostic test accuracy review (updated)

Mucolytics for children with chronic suppurative lung disease

Multimodal interventions for cachexia management

Music‐based therapeutic interventions for people with dementia (updated)

Next‐generation sequencing for guiding matched targeted therapies in people with relapsed or metastatic cancer

Nonsteroidal anti‐inflammatory drugs (NSAIDs) for acute renal colic (updated)

Non‐pharmacological and non‐surgical treatments for low back pain in adults: an overview of Cochrane reviews

Pelvic floor muscle training with feedback or biofeedback for urinary incontinence in women (updated)

Positron emission tomography‐adapted therapy for first‐line treatment in adults with Hodgkin lymphoma (updated)

Postoperative nutritional support after pancreaticoduodenectomy in adults

Red blood cell transfusion management for people undergoing cardiac surgery for congenital heart disease (updated)

Rituximab for people with multiple sclerosis (updated)

Safety and efficacy of proton pump inhibitors in preterm infants with gastroesophageal reflux disease

Sex as a prognostic factor for mortality in adults with acute symptomatic pulmonary embolism

Stakeholders’ perceptions and experiences of factors influencing the commissioning, delivery, and uptake of general health checks: a qualitative evidence synthesis

Sulfonylurea drugs for people with severe hemispheric ischemic stroke

Truenat MTB assays for pulmonary tuberculosis and rifampicin resistance in adults and adolescents

Ultrasound‐guided versus anatomic landmark‐guided percutaneous femoral artery access

Vasodilators for women undergoing fertility treatment (updated)

Withdrawal of antihypertensive drugs in older people (updated)

NICE guidelines

12 SQ-HDM SLIT for treating allergic rhinitis and allergic asthma caused by house dust mites (TA1045)

Alcohol-mediated perivascular renal sympathetic denervation for resistant hypertension (IPG801)

Blinatumomab with chemotherapy for consolidation treatment of Philadelphia-chromosome-negative CD19-positive minimal residual disease-negative B-cell precursor acute lymphoblastic leukaemia (TA1049)

Fenfluramine for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over (TA1050)

Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy when a stem cell transplant is suitable (TA1048)

Zolbetuximab with chemotherapy for untreated claudin-18.2-positive HER2-negative unresectable advanced gastric or gastro-oesophageal junction adenocarcinoma (TA1046)

Sources

Cochrane Library (Mar); NICE website (Mar)

March 2025

All content new unless marked as updated

Cochrane reviews

Acupuncture for neonatal abstinence syndrome in newborn infants

Angioplasty or stenting for deep venous thrombosis

Antidepressants versus placebo for generalised anxiety disorder (GAD)

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis (updated)

Balloon dilatation of the Eustachian tube for obstructive Eustachian tube dysfunction in adults

Breastfeeding interventions for preventing postpartum depression

Carbon dioxide detection for diagnosis of inadvertent respiratory tract placement of enterogastric tubes in children

Cardiovascular training for fatigue in people with cancer

Colchicine for the primary prevention of cardiovascular events

Diuretics for preventing and treating acute kidney injury

Electronic cigarettes for smoking cessation (updated)

Glucagon‐like peptide 1 (GLP‐1) receptor agonists for people with chronic kidney disease and diabetes

Home‐based educational interventions for children with asthma (updated)

Implementation strategies for WHO guidelines to prevent, detect, and treat postpartum hemorrhage

In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction (updated)

Influenza vaccination for healthcare workers who care for people aged 60 or older living in long‐term care institutions (updated)

Interventions for myopia control in children: a living systematic review and network meta‐analysis (updated)

Interventions to reduce non‐prescription antimicrobial sales in community pharmacies

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced epithelial ovarian cancer (updated)

Non‐vitamin K antagonist oral anticoagulants (NOACs) after transcatheter aortic valve replacement (TAVR): a network meta‐analysis

Physical rehabilitation approaches for the recovery of function and mobility following stroke (updated)

Precision nutrition‐based interventions for the management of obesity in children and adolescents up to the age of 19 years

Prophylactic transarterial embolization in patients with bleeding peptic ulcers following endoscopic control of bleeding

Renin inhibitors versus angiotensin receptor blockers for primary hypertension

Self‐management interventions for quality of life in adults with visual impairment

Transfusion of blood and blood products for the management of postpartum haemorrhage

Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis

Tumor necrosis factor (TNF) inhibitors for psoriatic arthritis

NICE guidelines

Advanced breast cancer: diagnosis and treatment (CG81 – updated)

Artificial intelligence-derived software to analyse chest X-rays for suspected lung cancer in primary care referrals: early value assessment (HTE12 – updated)

Digital technologies to support self-management of COPD: early value assessment (HTE19 – updated)

Durvalumab with etoposide and either carboplatin or cisplatin for untreated extensive-stage small-cell lung cancer

Early and locally advanced breast cancer: diagnosis and management (NG101 – updated)

Elacestrant for treating oestrogen receptor-positive HER2-negative advanced breast cancer with an ESR1 mutation after endocrine treatment (TA1036)

Exagamglogene autotemcel for treating severe sickle cell disease in people 12 years and over (TA1044)

Ganaxolone for treating seizures caused by CDKL5 deficiency disorder in people 2 years and over (TA1033)

Intravascular lithotripsy to treat calcified coronary arteries during percutaneous coronary intervention (IPG802)

Olaparib for treating BRCA mutation-positive HER2-negative advanced breast cancer after chemotherapy (TA1040)

Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resection (TA1043)

Ovarian cancer (QS18 – updated)

Pembrolizumab for adjuvant treatment of resected non-small-cell lung cancer (TA1037)

Selpercatinib for advanced thyroid cancer with RET alterations after treatment with a targeted cancer drug in people 12 years and over (TA1038)

Selpercatinib for advanced thyroid cancer with RET alterations untreated with a targeted cancer drug in people 12 years and over (TA 1039)

Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer (TA1042)

Tobacco: preventing uptake, promoting quitting and treating dependence (NG209 - updated)

Sources

Cochrane Library (Feb); NICE website (Feb)

February 2025

All content new, unless marked as ‘updated’

Cochrane reviews

Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women (updated)

Ankle‐foot orthoses for improving walking in adults with calf muscle weakness due to neuromuscular disorders

Antidepressants versus placebo for generalised anxiety disorder (GAD)

Anti‐PD‐1 and anti‐PD‐L1 antibodies for glioma

Caesarean myomectomy in pregnant women with uterine fibroids

Calorie (energy) labelling for changing selection and consumption of food or alcohol

Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status

Direct factor Xa inhibitors versus low molecular weight heparins or vitamin K antagonists for prevention of venous thromboembolism in elective primary hip or knee replacement or hip fracture repair

Diuretics for preventing and treating acute kidney injury

Electronic cigarettes for smoking cessation (updated)

Gonadotropin‐releasing hormone agonist protocols for pituitary suppression in assisted reproduction (updated)

Incentives for smoking cessation (updated)

Interrupted versus uninterrupted anticoagulation for cardiac rhythm management device insertion

Interventions for quitting vaping

Interventions implemented through sporting organisations for promoting healthy behaviour or improving health outcomes

Interventions to reduce non‐prescription antimicrobial sales in community pharmacies

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (updated)

Lurasidone versus typical antipsychotics for schizophrenia

Oral and intranasal aspirin desensitisation for non‐steroidal anti‐inflammatory drug (NSAID)‐exacerbated respiratory disease

Precision nutrition‐based interventions for the management of obesity in children and adolescents up to the age of 19 years

Preservation of the azygos vein versus ligation of the azygos vein during primary surgical repair of congenital esophageal atresia

Pre‐emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients (updated)

Tests for diagnosis of postpartum haemorrhage at vaginal birth

Thrombolysis for aneurysmal subarachnoid haemorrhage

Tranexamic acid for preventing postpartum haemorrhage after vaginal birth (updated)

Virtual reality for multiple sclerosis rehabilitation

NICE guidelines

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