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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Gastrointestinal Medicine and Surgery

Gastrointestinal Medicine and Surgery current awareness bulletin

Frequency: Bi-monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

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November 2025

Adiposity associations with risk of colorectal cancer: a systematic review

Associations of long-term night shift work with incident irritable bowel syndrome

Cholecystokinin: clinical aspects of the new biology

Diverticulitis: a review (JAMA)

Epidemiology, molecular biology, and genetics of sporadic young onset colorectal cancer

Factors affecting low health-related quality of life and health issues in gastric cancer survivors: a propensity score-matched, nationwide study

Fertility considerations young onset CRC

Global perspectives on young-onset colorectal cancer: epidemiology, challenges, and advances

Guselkumab for previously treated moderately to severely active Crohn's disease (new NICE guidance TA1095)

Guselkumab for treating moderately to severely active ulcerative colitis (new NICE guidance TA1094)

The gut microbiome in hyperuricemia and gout

Impact of introducing artificial intelligence on colonoscopy: a retrospective study on potential benefits and drawbacks

Impact of micro- and nanoplastics on gastrointestinal diseases: recent advances

Intraperitoneal chemotherapy for gastric cancer (new Cochrane review)

Intravenous rehydration for severe acute malnutrition with gastroenteritis

Low-dose aspirin for PI3K-altered localized colorectal cancer

Management of constipation in people receiving palliative care

Population health colorectal cancer screening strategies in adults aged 45 to 49 years: a randomized clinical trial

Risk factors for microscopic colitis: a systematic review and meta-analysis

Role of the dietitian in the inflammatory bowel disease multidisciplinary team

Screening colonoscopy yields among adults aged 45 to 49 years after lowering the colon cancer screening age

Smartphone use on the toilet and the risk of hemorrhoids

Time to definitive treatment in rectal cancer care coordination

Watch and wait in early onset rectal cancer patients: A review of the literature

Young onset colorectal cancer in hereditary syndromes

Young-onset colorectal cancer quality of life and psychosocial concerns

Sources

American Journal of Surgery (Oct); Arthritis & Rheumatology (Aug); Australian Journal of General Practice (Aug); Cochrane Library (Sep-Oct); European Journal of Internal Medicine (Sep); JAMA (Aug-Oct); Journal of Gastroenterology and Hepatology (Sep); Journal of Internal Medicine (Sep); NEJM (Sep-Oct); NICE website (Aug-Sep); Obesity (Aug); PLOS One (Sep); Seminars in Colon and Rectal Surgery (Sep)

September 2025

 Advancements and challenges in biomarker testing for tumors of the luminal gastrointestinal tract: current practice guidelines and emerging markers

The alarming rise of early-onset colorectal cancer

Approach to the management of gastrointestinal manifestations in patients with phaeochromocytoma and paraganglioma

Beyond the mucosa: unveiling selected mesenchymal lesions of the gastrointestinal tract

Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation

The bidirectional interplay between gut dysbiosis and surgical complications: a systematic review

Chemoradiotherapy and local excision vs total mesorectal excision in T2-T3ab, N0, M0 rectal cancer: the TAUTEM randomized clinical trial

Clinical validation of a circulating tumor DNA–based blood test to screen for colorectal cancer

Conversion to open surgery in laparoscopic approach of adhesive small bowel obstruction: predictive factors and its impact on short-term outcomes

Deep learning based colorectal cancer detection in medical images: a comprehensive analysis of datasets, methods, and future directions

Early onset colorectal cancer

Efficacy and safety of intravenous induction and subcutaneous maintenance therapy with guselkumab for patients with Crohn's disease (GALAXI-2 and GALAXI-3): 48-week results from two phase 3, randomised, placebo and active comparator-controlled, double-blind, triple-dummy trials

Encorafenib, cetuximab, and mFOLFOX6 in BRAF-mutated colorectal cancer

Exploring colorectal cancer patients' diagnostic pathways and general practitioners' assessment of the diagnostic processes: a Danish survey study

Fruquintinib for previously treated metastatic colorectal cancer (new NICE guideline TA1079)

Gastric cancer (Lancet seminar review)

Gut microbiome‐based interventions for the management of obesity in children and adolescents aged up to 19 years (new Cochrane intervention review)

High-touch vs low-touch strategy for implementing a CRC screening digital health intervention: a randomized clinical trial

Histologic evaluation of gastrointestinal biopsies from immunocompromised patients

Imaging features and preoperative diagnostic insights of esophageal schwannomas as a rare type

Inflammatory bowel disease and risk of rheumatoid arthritis: a UK Biobank cohort study

Laparoscopic insertion of an inactive implant for gastro-oesophageal reflux disease (new NICE guideline IPG803)

Long COVID and gut microbiome: insights into pathogenesis and therapeutics

Malnutrition in older adults

Mirikizumab for previously treated moderately to severely active Crohn's disease (new NICE guideline TA1080)

Multidose ondansetron after emergency visits in children with gastroenteritis

Neoadjuvant chemoradiotherapy vs chemoimmunotherapy for esophageal squamous cell carcinoma

Novel anal lesions not to overlook

One-piece closed bags for colostomies: late-stage assessment (new NICE guideline HTE29)

Perioperative durvalumab in gastric and gastroesophageal junction cancer

Robotic vs laparoscopic surgery for middle and low rectal cancer: the REAL randomized clinical trial

Sigmoid resection vs conservative treatment after diverticulitis: prespecified 4-year analysis of the LASER randomized clinical trial

Smokers with Crohn's face worse surgical outcomes: a 90-day perioperative analysis

Structured exercise after adjuvant chemotherapy for colon cancer

Surgical management of gastro-oesophageal reflux in children

Trastuzumab deruxtecan or ramucirumab plus paclitaxel in gastric cancer

Tumor necrosis factor‐alpha antagonists for treatment of pediatric Crohn’s disease (new Cochrane intervention review)

Sources

American Journal of Surgery, The (Jun-Sep); Australian Journal of General Practice (Jun); BMJ, The (Jun); Clinical Endocrinology (Jul); Clinical Imaging (Jun-Sep); Cochrane Library (Jul); Diagnostic Histopathology (Jun); Gut Microbes (Jan); International Journal of Rheumatic Diseases (Jun); JAMA (Jun-Jul); JAMA Internal Medicine (Jul); JAMA Surgery (May-Jul); Lancet, The (Jun-Jul); NEJM (Jun-Jul); NICE website (Jun-Jul); Scandinavian Journal of Primary Health Care (Jun); Surgery-Oxford (Aug)

July 2025

Advancing gastrointestinal microbiota research in systemic sclerosis

Approach to esophageal symptoms

Botox injections for esophageal motor disorders

Closure of mesenteric defects for prevention of internal hernia after Roux‐en‐Y gastric bypass in bariatric surgery (updated Cochrane intervention review)

Common gut microbial signatures in autism spectrum disorder and attention deficit hyperactivity disorder

Endoscopic management of reflux

The esophageal mucosa

The esophagogastric junction reconsidered

The genetic architecture of congenital diarrhea and enteropathy

Global trends, disparities, and future projections of ischemic stroke burden attributed to low-fiber diets

Gut and joint microbiomes

The gut microbiome and eating behavior outcomes: a systematic review

The gut microbiota as a link between colorectal cancer and obesity

High quality Barrett’s esophagus examination and endoscopic eradication therapy

Laparoscopic insertion of an inactive implant for gastro-oesophageal reflux disease (new NICE guideline IPG803)

Long-term outcomes of laparoscopic Roux-en-Y gastric bypass vs laparoscopic sleeve gastrectomy for obesity: the SM-BOSS randomized clinical trial

Management of esophageal strictures

Management of perforated peptic ulcer: a review

Motility assessment during endoscopy

Nivolumab plus ipilimumab for untreated unresectable or metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency (new NICE guideline TA1065)

Long-term outcomes of laparoscopic Roux-en-Y gastric bypass vs laparoscopic sleeve gastrectomy for obesity: the SM-BOSS randomized clinical trial

Management of esophageal strictures

Management of perforated peptic ulcer: a review

Motility assessment during endoscopy

Nivolumab plus ipilimumab for untreated unresectable or metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency

Peroral endoscopic myotomy and functional lumen imaging probe

Proton pump inhibitors for the prevention of non‐steroidal anti‐inflammatory drug‐induced ulcers and dyspepsia (new Cochrane intervention review)

Reflux testing

Sources

Autism Research (Apr); Cochrane Library (Apr-May); Gastrointestinal Endoscopy Clinics of North America (Jul); JAMA Surgery (Apr); Journal of Stroke and Cerebrovascular Diseases (Jun); NEJM (Apr); NICE website (May-Jun); Obesity Reviews (Apr); Rheumatic Disease Clinics of North America (May)

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