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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Blood

Blood current awareness bulletin

Frequency: Bi-monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

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September 2025

Association of iron deficiency and anemia with obesity among children: a systematic review and meta-analysis

Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants

Breakthrough hemolysis in paroxysmal nocturnal hemoglobinuria throughout clinical trials: from definition to clinical practice

Doubling down: the new deal in the clinical management of double-refractory chronic lymphocytic leukemia

The evolving landscape of hereditary stomatocytosis

Genome-wide meta-analysis of heavy menstrual bleeding reveals 36 risk loci

Haploidentical transplantation: an optimal platform for graft manipulation and cellular therapies

How I treat acute lymphoblastic leukemia in the era of immunotherapy while revisiting the myth of second remission

How I treat type 1 plasminogen deficiency

How I treat Wiskott-Aldrich syndrome

Innovations in red blood cell preservation

International consensus statement on diagnosis, evaluation, and research of Richter transformation: the ERIC recommendations

Low flow: selecting a limited flow cytometry panel where resources are constrained

Marstacimab for treating severe haemophilia A or B in people 12 years and over without anti-factor antibodies (new NICE guideline TA1073)

Metabolic pathways in deep vein thrombosis: a new frontier for therapeutic intervention

Neutrophils in BCR::ABL1 negative MPN: contributors or bystanders of fibrosis?

Pathogenesis of paroxysmal nocturnal hemoglobinuria

PI3Kγ in leukemia: class IB PI3 kinase reemerges as a cancer-intrinsic target

Practical guidance on the prevention and management of infection in multiple myeloma patients: a case-based approach

Proteostasis disruption in inherited bone marrow failure syndromes

Social determinants of health and access to allogeneic hematopoietic cell transplantation for acute myeloid leukemia

Ticagrelor doubts: inaccuracies uncovered in key studies for AstraZeneca’s billion dollar drug

Sources

Blood (19th Jun-7th Aug); Blood Reviews (Jul); BMJ, The (Jun); NICE website (Jun-Jul); Obesity Reviews (Jun)

July 2025

Advances in RNA editing in hematopoiesis and associated malignancies

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in adults over 70 years old

Approaching a therapeutic inflection point for FLT3-mutated AML

Artificial intelligence in haematopathology: current perspective and future directions

Blood under pressure: how climate change threatens blood safety and supply chains

Chronic myeloid leukemia: a review (JAMA)

Clinical-genomic profiling of MDS to inform allo-HCT: recommendations from an international panel on behalf of the EBMT

Clonal hematopoiesis landscape in frequent blood donors

Considerations on the dose and schedule of tyrosine kinase inhibitors for chronic myeloid leukemia: does dose matter?

Debating race and the diagnosis of anemia — how medicine moved away from race-based standards

Decoding functional hematopoietic progenitor cells in the adult human lung

EMZL at various sites: learning from each other

Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood

The fit older adult with acute myeloid leukemia: clinical challenges to providing evidence-based frontline treatment

How I approach pharmacological thromboprophylaxis in children

How I diagnose and treat cardiorespiratory complications of transfusion

How I manage major hemorrhage

How I manage pregnant patients who are alloimmunized to RBC antigens

How I treat AML relapse after allogeneic HSCT

How I treat challenging transfusion cases in sickle cell disease

How I treat higher-risk MDS

How I treat patients who are refractory to platelet transfusions

How I use noninvasive prenatal testing for red blood cell and platelet antigens

Identification of hepatic-like EPO as a cause of polycythemia

Immunoactinopathies revisited: understanding clinical manifestations and biological pathway

Iron deficiency in adults: a review (JAMA)

Ph-positive acute lymphoblastic leukemia — 25 years of progress

Precision medicine for high-risk gene fusions in pediatric AML: a focus on KMT2A, NUP98, and GLIS2 rearrangements

Sustained clinical benefit of AAV gene therapy in severe hemophilia B

TP53-mutated acute myeloid leukemia: how can we improve outcomes?

Vaccines for preventing infections in adults with haematological malignancies (new Cochrane intervention review)

Sources

Blood (1st May-12th June); Cochrane Library (May-Jun); Diagnostic Histopathology (May); JAMA (May); Journal of Clinical Investigation, The (May); Lancet Planetary Health, The (Apr); NEJM (Apr-Jun)

May 2025

Blinatumomab with chemotherapy for consolidation treatment of Philadelphia-chromosome-negative CD19-positive minimal residual disease-negative B-cell precursor acute lymphoblastic leukaemia (new NICE guideline TA1049)

Classification and risk stratification in T-lineage acute lymphoblastic leukemia

The contribution of the monocyte-macrophage lineage to immunotherapy outcomes

Don't break the (blood) bank: can waste be minimized in a whole blood program?

Essential thrombocythemia: a review

The evolution of treatment-free remission

FDA-approved therapies for chronic GVHD

Genetic subtypes of B-cell acute lymphoblastic leukemia in adults

Haemophilia (Lancet seminar)

Honing CAR T cells to tackle acute myeloid leukemia

How I diagnose and treat acute infection–associated purpura fulminans

How I manage patients with unexplained cytopenia

How I treat acute myeloid leukemia with differentiation therapy

How I treat patients with AML using azacitidine and venetoclax

How I treat quantitative fibrinogen disorders

How I treat secondary acute myeloid leukemia

How I use maintenance therapy in acute myeloid leukemia

Illustrated capsules from the Advanced Course in Platelet Research

Impact of new medications on the treatment of immune TTP

Incorporation of immunotherapy into frontline treatment for adults with B-cell precursor acute lymphoblastic leukemia

Long-term outcomes of tyrosine kinase inhibitors in chronic myeloid leukemia

Novel mechanisms of resistance in CLL: variant BTK mutations in second-generation and noncovalent BTK inhibitors

Novel treatment strategies for chronic myeloid leukemia

The present and future of CAR T-cell therapy for adult B-cell ALL

Red blood cell transfusion management for people undergoing cardiac surgery for congenital heart disease (new Cochrane intervention review)

The United Kingdom Infected Blood Inquiry: its findings and lessons for the future of transfusion

Sources

American Journal of Surgery (Feb); Blood (20th Feb - 10th Apr); Cochrane Library (Mar-Apr); JAMA (Feb); Lancet, The (Mar); NICE website (Mar); Research and Practice in Thrombosis and Haemostasis (Feb)

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