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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Blood

Blood current awareness bulletin

Frequency: Bi-monthly

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November 2025

Acute lymphocytic leukaemia (Lancet review)

Association of Epstein-Barr virus genomic alterations with human pathologies

Beyond the iron gate: therapeutic donation at Lifeblood for patients with haemochromatosis

Biology as vulnerability in follicular lymphoma: genetics, epigenetics, and immunogenetics

Challenges in GVHD and GVL after hematopoietic stem cell transplantation for myeloid malignancies

Combined PET and ctDNA response as a predictor of POD24 for follicular lymphoma after first-line induction treatment

Deciphering the dynamics of histone acetylation and chromatin remodeling in multiple myeloma: a tale beyond the tails

End points and outcomes in follicular lymphoma: what should we measure, how, and why?

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: a systematic literature review highlighting insights from clinical trials and real-world studies

Exploring the thrombus niche: lessons learned and potential therapeutic opportunities

Factor XIII: driving (cross-)links in hemostasis, thrombosis, and disease

Frontline treatment of follicular lymphoma: what will it take to change current practice?

The future of follicular lymphoma management: strategies on the horizon

Hitting the therapeutic bull’s-eye with targeted therapy for patients with chronic lymphocytic leukemia

How I treat pediatric pulmonary embolism

Immune alterations in myeloma evolution and outcomes: quo vadis?

Inflammatory memory of stem cells: implications for hematologic diseases

The incidence, characteristics, management and outcomes of peripartum hyponatraemia in the United Kingdom: a prospective study using the UK Obstetric Surveillance System (UKOSS)

Measurable residual disease–guided therapy for chronic lymphocytic leukemia

Medical imaging and pediatric and adolescent hematologic cancer risk

Monoclonal gammopathy of undetermined significance (NEJM review)

Navigating acute myeloid leukemia towards better outcomes: treatment pathways and challenges for patients ineligible for intensive chemotherapy

Navigating the dynamic landscape of lower-risk MDS: advances and emerging insights

The new era of primary immune thrombocytopenia management in adults: a narrative review of current and emerging treatments

New prognostic systems for multiple myeloma in the context of contemporary therapies

Platelet activation and signaling in thrombus formation

Platelet transfusion: 2025 AABB and ICTMG International clinical practice guidelines

Structure and interactions of the proteins from the contact system

Structure-based design of therapeutics to control hemostasis

Suppression to removal, an emerging therapeutic approach for AL amyloidosis: a comprehensive review with early human data and pharmacokinetics of CAEL-101 antibody

Transplant-acquired allergy in HCT-recipients: reference for clinical management

Treatment of relapsed and refractory follicular lymphoma: which treatment for which patient for which line of therapy?

An updated understanding of follicular lymphoma transformation

Visualizing amyloidosis: the role of radionuclide imaging in systemic amyloidosis

Sources

Australian Journal of General Practice (Sep); BJOG (Sep); Blood (28th Aug-9th Oct); Blood Reviews (Aug); JAMA (Aug); Lancet (Aug); NEJM (Sep-Oct)

September 2025

Association of iron deficiency and anemia with obesity among children: a systematic review and meta-analysis

Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants

Breakthrough hemolysis in paroxysmal nocturnal hemoglobinuria throughout clinical trials: from definition to clinical practice

Doubling down: the new deal in the clinical management of double-refractory chronic lymphocytic leukemia

The evolving landscape of hereditary stomatocytosis

Genome-wide meta-analysis of heavy menstrual bleeding reveals 36 risk loci

Haploidentical transplantation: an optimal platform for graft manipulation and cellular therapies

How I treat acute lymphoblastic leukemia in the era of immunotherapy while revisiting the myth of second remission

How I treat type 1 plasminogen deficiency

How I treat Wiskott-Aldrich syndrome

Innovations in red blood cell preservation

International consensus statement on diagnosis, evaluation, and research of Richter transformation: the ERIC recommendations

Low flow: selecting a limited flow cytometry panel where resources are constrained

Marstacimab for treating severe haemophilia A or B in people 12 years and over without anti-factor antibodies (new NICE guideline TA1073)

Metabolic pathways in deep vein thrombosis: a new frontier for therapeutic intervention

Neutrophils in BCR::ABL1 negative MPN: contributors or bystanders of fibrosis?

Pathogenesis of paroxysmal nocturnal hemoglobinuria

PI3Kγ in leukemia: class IB PI3 kinase reemerges as a cancer-intrinsic target

Practical guidance on the prevention and management of infection in multiple myeloma patients: a case-based approach

Proteostasis disruption in inherited bone marrow failure syndromes

Social determinants of health and access to allogeneic hematopoietic cell transplantation for acute myeloid leukemia

Ticagrelor doubts: inaccuracies uncovered in key studies for AstraZeneca’s billion dollar drug

Sources

Blood (19th Jun-7th Aug); Blood Reviews (Jul); BMJ, The (Jun); NICE website (Jun-Jul); Obesity Reviews (Jun)

July 2025

Advances in RNA editing in hematopoiesis and associated malignancies

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in adults over 70 years old

Approaching a therapeutic inflection point for FLT3-mutated AML

Artificial intelligence in haematopathology: current perspective and future directions

Blood under pressure: how climate change threatens blood safety and supply chains

Chronic myeloid leukemia: a review (JAMA)

Clinical-genomic profiling of MDS to inform allo-HCT: recommendations from an international panel on behalf of the EBMT

Clonal hematopoiesis landscape in frequent blood donors

Considerations on the dose and schedule of tyrosine kinase inhibitors for chronic myeloid leukemia: does dose matter?

Debating race and the diagnosis of anemia — how medicine moved away from race-based standards

Decoding functional hematopoietic progenitor cells in the adult human lung

EMZL at various sites: learning from each other

Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood

The fit older adult with acute myeloid leukemia: clinical challenges to providing evidence-based frontline treatment

How I approach pharmacological thromboprophylaxis in children

How I diagnose and treat cardiorespiratory complications of transfusion

How I manage major hemorrhage

How I manage pregnant patients who are alloimmunized to RBC antigens

How I treat AML relapse after allogeneic HSCT

How I treat challenging transfusion cases in sickle cell disease

How I treat higher-risk MDS

How I treat patients who are refractory to platelet transfusions

How I use noninvasive prenatal testing for red blood cell and platelet antigens

Identification of hepatic-like EPO as a cause of polycythemia

Immunoactinopathies revisited: understanding clinical manifestations and biological pathway

Iron deficiency in adults: a review (JAMA)

Ph-positive acute lymphoblastic leukemia — 25 years of progress

Precision medicine for high-risk gene fusions in pediatric AML: a focus on KMT2A, NUP98, and GLIS2 rearrangements

Sustained clinical benefit of AAV gene therapy in severe hemophilia B

TP53-mutated acute myeloid leukemia: how can we improve outcomes?

Vaccines for preventing infections in adults with haematological malignancies (new Cochrane intervention review)

Sources

Blood (1st May-12th June); Cochrane Library (May-Jun); Diagnostic Histopathology (May); JAMA (May); Journal of Clinical Investigation, The (May); Lancet Planetary Health, The (Apr); NEJM (Apr-Jun)

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