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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Blood

Blood current awareness bulletin

Frequency: Bi-monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

To receive email notifications about new issues of this bulletin, please email: richard.fallis@healthcarelibrary.qub.ac.uk

March 2025

Acute promyelocytic leukemia: long-term outcomes from the HARMONY project

Andexanet alfa for reversing anticoagulation from apixaban or rivaroxaban (updated NICE guideline TA697)

β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy

Building the future management of follicular lymphoma with T-cell–redirecting strategies

Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria

The current landscape of frontline large B-cell lymphoma trials

Current myeloproliferative neoplasm scoring systems for clinical practice

Frontline management of mantle cell lymphoma

Genetic and clinical spectrum of SAMD9 and SAMD9L syndromes: from variant interpretation to patient management

Genetic iron overload aggravates, and pharmacological iron restriction improves, MDS pathophysiology in a preclinical study

High-risk MCL: recognition and treatment

How I treat/manage:

Management of iron overload: lessons from transfusion-dependent hemoglobinopathies

Menin inhibitors in the treatment of acute myeloid leukemia

Palliative care in hematology: a systematic review of the components, effectiveness, and implementation

Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19

Transfusion of blood and blood products for the management of postpartum haemorrhage (new Cochrane intervention review)

Treatment of relapsed/refractory MCL

Unraveling MCL biology to understand resistance and identify vulnerabilities

Vadadustat for treating symptomatic anaemia in adults having dialysis for chronic kidney disease (new NICE guideline TA1035

Sources

Blood (Jan-13th Feb); Cochrane Library (Feb); Journal of Pain and Symptom Management (Jan); NICE website (Jan-Feb)

January 2025

Are we there yet? CAR-T therapy in multiple myeloma

Blood coagulation factor IX: structural insights impacting hemophilia B therapy

Cell salvage for the management of postpartum haemorrhage (new Cochrane review)

Central nervous system prophylaxis in large B-cell lymphoma: a British Society for Haematology Good Practice Paper

Chimeric antigen receptor T-cell therapy for haematological malignancies

Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy

Coagulation factor VIII: biological basis of emerging hemophilia A therapies

Dialysis for chronic kidney failure: a review

DLBCL: who is high risk and how should treatment be optimized?

Effect and safety of intravenous iron compared to oral iron for treatment of iron deficiency anaemia in pregnancy (new Cochrane review)

Exploring the role of Large Language Models in haematology: a focused review of applications, benefits and limitations

            See also: The power and perils of large language models in haematology

Haemodiafiltration versus haemodialysis for kidney failure

The high-grade B-cell lymphomas: double hit and more

How unique structural adaptations support and coordinate the complex function of von Willebrand factor

Paediatric relapsed acute leukaemia: curative intent chemotherapy improves quality of life

Peripheral T-cell lymphoma: are all patients high risk?

Perspectives on drug development in chronic myelomonocytic leukemia: changing the paradigm

Platelet generation in vivo and in vitro

Primary large B-cell lymphomas of immune-privileged sites

RNA-loaded nanoparticles for the treatment of hematological cancers

Sequencing of therapy for patients with diffuse large B-cell lymphoma in the era of novel drugs

T-cell lymphomas in recipients of CAR-T cells: assessing risks and causalities

Therapeutic strategies targeting aberrant RNA splicing in myeloid malignancies

Treatment for women with postpartum iron deficiency anaemia (updated Cochrane review)

Understanding splenic B-cell lymphoma/leukaemia with prominent nucleoli: diagnosis, underpinnings for disease classification and future directions

Sources

Advanced Drug Delivery Reviews (Nov); Blood (Nov-Dec); BMJ Supportive and Palliative Care (Nov); British Journal of Haematology (Nov-Dec); Cochrane Library (Dec); JAMA (Nov); Lancet, The (Nov)

November 2024

Advanced imaging for earlier diagnosis and morbidity prevention in multiple myeloma

Antiemetic prophylaxis regimens in haematologic malignancies patients undergoing a hematopoietic stem cell transplantation. Which is the best standard of care? A systematic review

Blood biomarkers to detect Alzheimer disease in primary care and secondary care

Changes in Alzheimer disease blood biomarkers and associations with incident all-cause dementia

Clinical utility of investigations in triple-negative thrombocytosis: a real-world, multicentre evaluation of UK practice

Cryoglobulinemia — one name for two diseases

Current and upcoming treatment approaches to common subtypes of PTCL (PTCL, NOS; ALCL; and TFHs)

See also: Current and upcoming treatment approaches to uncommon subtypes of PTCL (EATL, MEITL, SPTCL, and HSTCL)

Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials

Hairy-cell leukemia (NEJM review)

Hope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation

How do we manage hyperhemolysis syndrome?

How I treat acute venous thromboembolism in patients with brain tumors

The impact of hematology electronic consultations on the management of iron deficiency

The intestinal microbiota and cellular therapy: implications for impact and mechanisms

Measurement of heparin, direct oral anti-coagulants and other non-coumarin anti-coagulants and their effects on haemostasis assays: a British Society for Haematology Guideline

A modern view of LGL leukemia

New insights into the biology of T-cell lymphomas

Novel functions for von Willebrand factor

A practical approach to the modern diagnosis and classification of T- and NK-cell lymphomas

A rapid review of motives and barriers for living substance of human origin donation and an extended typology

Revisiting the full blood count: circulating blood cells and their role in coagulation

Transfusion Camp: the UK experience and its value in improving knowledge of transfusion medicine among postgraduate trainees

The use of predictive modelling to determine the likelihood of donor return during the COVID-19 pandemic

Sources

Blood (12th Sep-31st Oct); British Journal of Haematology (Oct); European Journal of Haematology (Nov); JAMA (Oct); NEJM (Oct); Transfusion (Oct); Transfusion Medicine (Oct)

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