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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Blood

Blood current awareness bulletin

Frequency: Bi-monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

To receive email notifications about new issues of this bulletin, please email: richard.fallis@healthcarelibrary.qub.ac.uk

January 2025

Are we there yet? CAR-T therapy in multiple myeloma

Blood coagulation factor IX: structural insights impacting hemophilia B therapy

Cell salvage for the management of postpartum haemorrhage (new Cochrane review)

Central nervous system prophylaxis in large B-cell lymphoma: a British Society for Haematology Good Practice Paper

Chimeric antigen receptor T-cell therapy for haematological malignancies

Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy

Coagulation factor VIII: biological basis of emerging hemophilia A therapies

Dialysis for chronic kidney failure: a review

DLBCL: who is high risk and how should treatment be optimized?

Effect and safety of intravenous iron compared to oral iron for treatment of iron deficiency anaemia in pregnancy (new Cochrane review)

Exploring the role of Large Language Models in haematology: a focused review of applications, benefits and limitations

            See also: The power and perils of large language models in haematology

Haemodiafiltration versus haemodialysis for kidney failure

The high-grade B-cell lymphomas: double hit and more

How unique structural adaptations support and coordinate the complex function of von Willebrand factor

Paediatric relapsed acute leukaemia: curative intent chemotherapy improves quality of life

Peripheral T-cell lymphoma: are all patients high risk?

Perspectives on drug development in chronic myelomonocytic leukemia: changing the paradigm

Platelet generation in vivo and in vitro

Primary large B-cell lymphomas of immune-privileged sites

RNA-loaded nanoparticles for the treatment of hematological cancers

Sequencing of therapy for patients with diffuse large B-cell lymphoma in the era of novel drugs

T-cell lymphomas in recipients of CAR-T cells: assessing risks and causalities

Therapeutic strategies targeting aberrant RNA splicing in myeloid malignancies

Treatment for women with postpartum iron deficiency anaemia (updated Cochrane review)

Understanding splenic B-cell lymphoma/leukaemia with prominent nucleoli: diagnosis, underpinnings for disease classification and future directions

Sources

Advanced Drug Delivery Reviews (Nov); Blood (Nov-Dec); BMJ Supportive and Palliative Care (Nov); British Journal of Haematology (Nov-Dec); Cochrane Library (Dec); JAMA (Nov); Lancet, The (Nov)

November 2024

Advanced imaging for earlier diagnosis and morbidity prevention in multiple myeloma

Antiemetic prophylaxis regimens in haematologic malignancies patients undergoing a hematopoietic stem cell transplantation. Which is the best standard of care? A systematic review

Blood biomarkers to detect Alzheimer disease in primary care and secondary care

Changes in Alzheimer disease blood biomarkers and associations with incident all-cause dementia

Clinical utility of investigations in triple-negative thrombocytosis: a real-world, multicentre evaluation of UK practice

Cryoglobulinemia — one name for two diseases

Current and upcoming treatment approaches to common subtypes of PTCL (PTCL, NOS; ALCL; and TFHs)

See also: Current and upcoming treatment approaches to uncommon subtypes of PTCL (EATL, MEITL, SPTCL, and HSTCL)

Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials

Hairy-cell leukemia (NEJM review)

Hope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation

How do we manage hyperhemolysis syndrome?

How I treat acute venous thromboembolism in patients with brain tumors

The impact of hematology electronic consultations on the management of iron deficiency

The intestinal microbiota and cellular therapy: implications for impact and mechanisms

Measurement of heparin, direct oral anti-coagulants and other non-coumarin anti-coagulants and their effects on haemostasis assays: a British Society for Haematology Guideline

A modern view of LGL leukemia

New insights into the biology of T-cell lymphomas

Novel functions for von Willebrand factor

A practical approach to the modern diagnosis and classification of T- and NK-cell lymphomas

A rapid review of motives and barriers for living substance of human origin donation and an extended typology

Revisiting the full blood count: circulating blood cells and their role in coagulation

Transfusion Camp: the UK experience and its value in improving knowledge of transfusion medicine among postgraduate trainees

The use of predictive modelling to determine the likelihood of donor return during the COVID-19 pandemic

Sources

Blood (12th Sep-31st Oct); British Journal of Haematology (Oct); European Journal of Haematology (Nov); JAMA (Oct); NEJM (Oct); Transfusion (Oct); Transfusion Medicine (Oct)

September 2024

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy

Chronic lymphocytic leukaemia (Lancet seminar review)

Cord blood banking: experts raise concern over claims made for stem cell applications

Current challenges in conditioning regimens for MDS transplantation

Dismantling relapsed/refractory mantle cell lymphoma

Elevating fetal hemoglobin: recently discovered regulators and mechanisms

Emerging genetic technologies informing personalized medicine in Shwachman-Diamond syndrome and other inherited BMF disorders

Evaluating minimal residual disease as an intermediate clinical end point for multiple myeloma

The global blood donation index: an imperfect measure of transfusion need

Gut microbiome composition and dysbiosis in immune thrombocytopenia: a review of literature

Hemoglobin Bart’s hydrops fetalis: charting the past and envisioning the future

Hot under the clot: venous thrombogenesis is an inflammatory process

Household water lead and hematologic toxic effects in chronic kidney disease

How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients

How I treat bleeding in hereditary hemorrhagic telangiectasia

How I use next-generation sequencing–MRD to plan approach and prevent relapse after HCT for children and adults with ALL

IL-1 in aging and pathologies of hematopoietic stem cells

Immune thrombocytopenia: pathophysiology and impacts of Romiplostim treatment

Iron, hemochromatosis genotypes, and risk of infections

Momelotinib for the treatment of myelofibrosis

A moonlighting job for α-globin in blood vessels

New frameworks for hematopoiesis derived from single-cell genomics

Novel therapeutic approaches in thalassemias, sickle cell disease, and other red cell disorders

Procoagulant platelets promote immune evasion in triple-negative breast cancer

Thrombotic events associated with immune checkpoint inhibitors and novel antithrombotic strategies to mitigate bleeding risk

Sources

Blood (11th July-5th Sep); Blood Reviews (Sep); BMJ, The (Jul); JAMA Internal Medicine (Jul); Lancet, The (Aug-Sep)

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