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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: Blood

Blood current awareness bulletin

Frequency: Bi-monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

To receive email notifications about new issues of this bulletin, please email: richard.fallis@healthcarelibrary.qub.ac.uk

September 2024

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy

Chronic lymphocytic leukaemia (Lancet seminar review)

Cord blood banking: experts raise concern over claims made for stem cell applications

Current challenges in conditioning regimens for MDS transplantation

Dismantling relapsed/refractory mantle cell lymphoma

Elevating fetal hemoglobin: recently discovered regulators and mechanisms

Emerging genetic technologies informing personalized medicine in Shwachman-Diamond syndrome and other inherited BMF disorders

Evaluating minimal residual disease as an intermediate clinical end point for multiple myeloma

The global blood donation index: an imperfect measure of transfusion need

Gut microbiome composition and dysbiosis in immune thrombocytopenia: a review of literature

Hemoglobin Bart’s hydrops fetalis: charting the past and envisioning the future

Hot under the clot: venous thrombogenesis is an inflammatory process

Household water lead and hematologic toxic effects in chronic kidney disease

How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients

How I treat bleeding in hereditary hemorrhagic telangiectasia

How I use next-generation sequencing–MRD to plan approach and prevent relapse after HCT for children and adults with ALL

IL-1 in aging and pathologies of hematopoietic stem cells

Immune thrombocytopenia: pathophysiology and impacts of Romiplostim treatment

Iron, hemochromatosis genotypes, and risk of infections

Momelotinib for the treatment of myelofibrosis

A moonlighting job for α-globin in blood vessels

New frameworks for hematopoiesis derived from single-cell genomics

Novel therapeutic approaches in thalassemias, sickle cell disease, and other red cell disorders

Procoagulant platelets promote immune evasion in triple-negative breast cancer

Thrombotic events associated with immune checkpoint inhibitors and novel antithrombotic strategies to mitigate bleeding risk

Sources

Blood (11th July-5th Sep); Blood Reviews (Sep); BMJ, The (Jul); JAMA Internal Medicine (Jul); Lancet, The (Aug-Sep)

July 2024

Advances in the treatment of Philadelphia chromosome negative acute lymphoblastic leukemia 10.1016/j.blre.2024.101208

Blood and guts: how the intestinal microbiome shapes hematopoiesis and treatment of hematologic disease 10.1182/blood.2023021174

Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress 10.1182/blood.2023023788

Current status and prospect of anti-amyloid fibril therapy in AL amyloidosis 10.1016/j.blre.2024.101207

DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies 10.1182/blood.2023019963

Early palliative care in haematological malignancies 10.1136/spcare-2024-004812

Escape from T-cell–targeting immunotherapies in acute myeloid leukemia 10.1182/blood.2023019961

Effectiveness of ferritin-guided donation intervals in whole-blood donors in the Netherlands (FIND'EM): a stepped-wedge cluster-randomised trial 10.1016/S0140-6736(24)01085-7

Evidence for antigen presentation by human neutrophils 10.1182/blood.2023023444

Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis 10.1182/blood.2023022736

How I treat long-term survivors of childhood acute leukemia 10.1182/blood.2023019804

How I treat the co-occurrence of venous and arterial thromboembolism: anticoagulation, antiplatelet therapy, or both? 10.1182/blood.2023021638

How I use genomics and BTK inhibitors in the treatment of Waldenström macroglobulinemia 10.1182/blood.2022017235

Ivosidenib with azacitidine for untreated acute myeloid leukaemia with an IDH1 R132 mutation (new NICE guideline TA979)

Malignant progression of preleukemic disorders 10.1182/blood.2023020817

Short-term and long-term survival in patients with prevalent haemodialysis—an integrated prognostic model: external validation 10.1136/spcare-2022-003916

Tricking the trickster: precision medicine approaches to counteract leukemia immune escape after transplant 10.1182/blood.2023019962

Voxelotor for treating haemolytic anaemia caused by sickle cell disease (new NICE guideline TA981)

What clinicians should know about surrogate end points in hematologic malignancies 10.1182/blood.2023022269

Sources

Blood (25th Apr-4th Jul); Blood Reviews (Jul); BMJ Supportive and Palliative Care (Jun); Lancet, The (Jul); NICE website (Jun)

May 2024

Arteriovenous access for hemodialysis: a review 10.1001/jama.2024.0535

BCMA- or GPRC5D-targeting bispecific antibodies in multiple myeloma: efficacy, safety, and resistance mechanisms 10.1182/blood.2023022499

Biology of factor XI (review) 10.1182/blood.2023020719

Cell cross talk within the lymphoma tumor microenvironment: follicular lymphoma as a paradigm 10.1182/blood.2023021000

Consensus recommendations on the management of toxicity associated with CD3×CD20 bispecific antibody therapy 10.1182/blood.2023022432

Degraders upgraded: the rise of PROTACs in hematological malignancies 10.1182/blood.2023022993

The essential microenvironmental role of oligomannoses specifically inserted into the antigen-binding sites of lymphoma cells 10.1182/blood.2023022703

Factor XI deficiency: phenotypic age-related considerations and clinical approach towards bleeding risk assessment 10.1182/blood.2023020721

The follicular lymphoma tumor microenvironment at single-cell and spatial resolution 10.1182/blood.2023020999

Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma 10.1182/blood.2023021002

Home versus inā€centre haemodialysis for people with kidney failure (updated Cochrane intervention review) 10.1002/14651858.CD009535.pub3

How I manage acute respiratory failure in patients with hematological malignancies 10.1182/blood.2023021414

How I reduce and treat posttransplant relapse of MDS 10.1182/blood.2023023005

Kurin Lock for blood culture collection (new NICE guideline MTG77)

Recent developments in the use of pyruvate kinase activators as a new approach for treating sickle cell disease 10.1182/blood.2023021167

T-cell dysfunctions in myelodysplastic syndromes 10.1182/blood.2023023166

Targeting factor XI and factor XIa to prevent thrombosis 10.1182/blood.2023020722

“Treatment with curative intent”: the emergence of genetic therapies for sickle cell anemia 10.1182/blood.2023021598

Sources

Blood (Mar-18th Apr); Cochrane Library (Mar-Apr); JAMA (18th Mar); NICE website (Apr)