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HSC Medicine, Dentistry and Healthcare Sciences Current Awareness Bulletins: General Internal Medicine

General Internal Medicine current awareness bulletin

Frequency: Bi-monthly

Links to articles in the current and previous 2 issues of this bulletin are displayed below.

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October 2025

2025 guidelines for direct oral anticoagulants: a practical guidance on the prescription, laboratory testing, peri-operative and bleeding management

Advances in management of pulmonary fibrosis

Antimicrobials in serious illness and end-of-life care: lifting the veil of silence

Beyond time as the healer: action in long COVID treatment to improve patient outcomes

Challenges for implementing generative artificial intelligence (GenAI) into clinical healthcare

Cholecystokinin: clinical aspects of the new biology

The effects of sleep improving interventions in medical hospital wards: the WEsleep study - a randomized clinical trial

Gaucher disease, state of the art and perspectives

Glucose-lowering medications, glycemia, and cognitive outcomes: the GRADE randomized clinical trial

Improving empiric antibiotic selection for patients hospitalized with abdominal infection: the INSPIRE 4 cluster randomized clinical trial

Lipoprotein (a): a new target for pharmacological research and an option for treatment

Living with an intolerance to medication

Lorundrostat in participants with uncontrolled hypertension and treatment-resistant hypertension: the Launch-HTN randomized clinical trial

Low-dose methotrexate for the treatment of inflammatory knee osteoarthritis: a randomized clinical trial

The medical ward round: evidence, pitfalls, and tips

Oral anticoagulation and risk of adverse clinical outcomes in venous thromboembolism

Pharmaceutical pitfalls in treating patients with advanced cancer

Physician- and large language model–generated hospital discharge summaries

Statin therapy for children

The TP53 tumor suppressor gene: from molecular biology to clinical investigations

Trends and disparities in maternal self-reported mental and physical health

Sources

Australian Journal of General Practice (Aug); BMJ, The (Jul); European Journal of Internal Medicine (Aug-Sep); Internal Medicine Journal (Jul); JAMA (Aug); JAMA Internal Medicine (Jul); JAMA Surgery (Jul); Journal of Internal Medicine (Aug-Sep); Lancet Infectious Diseases, The (Jul); NEJM (Jul)

August 2025

Abortion care (updated NICE guideline NG140)

Advancements in multiple sclerosis

Community care navigation intervention for people who are at risk of unplanned hospital presentations (new Cochrane intervention review)

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

COVID-19 rapid guideline: managing COVID-19 (updated NICE guideline NG191)

Dad's legacy: epigenetic reprogramming and paternal inflammatory memory in offspring health

Drug-induced hyponatremia in clinical care

Excess mortality of critically ill patients aged ≥90 years in intensive care units: a retrospective cohort study

Generalisation of placebo and nocebo effects: current knowledge and future directions

Gonadotropin‐releasing hormone (GnRH) analogues for premenstrual syndrome (PMS) (new Cochrane intervention review)

Headaches in over 12s: diagnosis and management (updated NICE guideline CG150)

Hormonal contraception for women at risk of HIV infection (new Cochrane intervention review)

Intermediate care units in internal medicine

Interventions to prevent obesity in children aged 2 to 4 years old (new Cochrane intervention review)

Iron deficiency in adults: a review (JAMA)

Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19 (updated NICE guideline TA878)

A person-centered approach to supplemental oxygen therapy in the outpatient setting: a review

Risk of major congenital malformations following prenatal exposure to smoking cessation medicines

Suspected cancer: recognition and referral (updated NICE guideline NG12)

Ticagrelor doubts: inaccuracies uncovered in key studies for AstraZeneca’s billion dollar drug

The use of telemedicine services for medical abortion (new Cochrane intervention review)

Sources

BMJ, The (Jun); Cochrane Library (Jun); European Journal of Internal Medicine (Jul); European Journal of Pain (Jul); JAMA (May); Internal Medicine Journal (Jun); JAMA Internal Medicine (Jun); Journal of Internal Medicine (Jul); NICE website (May-Jun)

June 2025

Buprenorphine, pain, and opioid use in patients taking high-dose long-term opioids

Butter and plant-based oils intake and mortality

Comparative bleeding risk in older patients with HIV and atrial fibrillation receiving oral anticoagulants

Delivery of intravenous anti‐cancer therapy at home versus in hospital or community settings for adults with cancer (new Cochrane intervention review)

Diagnosis and management of monoclonal gammopathy of undetermined significance: a review

Early and locally advanced breast cancer: diagnosis and management (updated NICE guideline NG101)

Entecavir for children and adults with chronic hepatitis B (new Cochrane intervention review)

Evaluation of preventive medicine amongst people living with human immunodeficiency virus attending a hospital-based care setting

Glucose-lowering medications and risk of chronic obstructive pulmonary disease exacerbations in patients with type 2 diabetes

Measuring the fitted filtration efficiency of cloth masks, medical masks and respirators

Melatonin in cancer treatment (new Cochrane intervention review)

Molnupiravir for treating COVID-19 (new NICE guideline TA1056)

Multivitamins after myocardial infarction in patients with diabetes: a randomized clinical trial

Non-invasive screening for coronary artery disease: current perspectives, patient, public health and ethical considerations in evaluating symptomatic and asymptomatic individuals

Nudging clinicians to promote serious illness communication for critically ill patients

Preventive medication deprescribing in advanced cancer patients approaching end of life

Proton pump inhibitors for the prevention of non‐steroidal anti‐inflammatory drug‐induced ulcers and dyspepsia (new Cochrane intervention review)

Severe sepsis-associated acute kidney injury and outcomes: a longitudinal cohort study

Statin use and risk of hepatocellular carcinoma and liver fibrosis in chronic liver disease

Termination of resuscitation rules for in-hospital cardiac arrest

Vaccines for preventing infections in adults with solid tumours (new Cochrane intervention review)

Sources

Cochrane Library (Apr-May); Internal Medicine Journal (Apr); JAMA Internal Medicine (Apr-May); NICE website (Apr); PLOS One (Apr)

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